结合珠蛋白

这项检测测定血液中结合珠蛋白的含量。结合珠蛋白是由肝脏产生，与血液中游离血红蛋白相结合的一种蛋白质。结合后的复合物很快被肝脏以破坏或再利用的形式清除。血红蛋白是机体运输氧气的蛋白质，通常只存在于红细胞（RBCs）中；在红细胞未被破坏时，只有少量血红蛋白游离存在。当大量红细胞被破坏，血液中结合珠蛋白的浓度因消耗程度超过肝脏生产速度而出现暂时降低。

        遗传性或获得性原因引起红细胞溶血，输血反应、某些药物和/或人工心脏瓣膜等引起的机械性损伤可增加红细胞的破坏。红细胞的破坏程度可轻微或严重，可分为急性和慢性，最终可导致溶血性贫血。溶血性贫血患者通常表现为疲倦、虚弱、呼吸急促、皮肤苍白或黄疸。

        肝脏疾病因肝脏受损抑制结合珠蛋白的生成，以及清除结合珠蛋白-游离血红蛋白复合物的能力下降，同样可以影响结合珠蛋白的浓度。

自肘静脉采集血液样本。

不需要任何准备。

疾病: 贫血, 肝脏疾病, 黄疸

American Family Physician: Hemolytic Anemia
National Heart Lung and Blood Institute: What is Hemolytic Anemia?
EMedicine: Hemolytic Anemia

Sources Used in Current Review

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp 199.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 512-513.

Thomas, Clayton L., Editor (1997). Taber’s Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pp 840.

Levin, M. (2007 March 8). Haptoglobin. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003634.htm . Accessed on 11/23/08.

(2006 September). What is Hemolytic Anemia? National Heart Lung and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/ha/ha_whatis.html through http://www.nhlbi.nih.gov. Accessed on 11/23/08.

Schick, P. (2007 January 29). Hemolytic Anemia. eMedicine [On-line information]. Available online at http://www.emedicine.com/med/TOPIC979.HTM through http://www.emedicine.com. Accessed on 11/23/08.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber’s Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby’s Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO. Pp 466-467.

(© 2005). Haptoglobin. ARUP’s Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_291a.jsp#4273706 through http://www.aruplab.com/.

Dhaliwal, G. et. al. (2004 June 1). Hemolytic Anemia. American Family Physician [On-line journal]. Available online at http://www.aafp.org/afp/20040601/2599.html through http://www.aafp.org.

Nanda, R., Updated (2005 February 1). Haptoglobin. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003634.htm.

(© 1995-2005). Autoimmune Hemolytic Anemia. Merck Manual-Second Home Edition [On-line information]. Available online at http://www.merck.com/mmhe/sec14/ch172/ch172f.html?qt=haptoglobin&alt=sh through http://www.merck.com.

O-Hara Paggen, M. (1999 September 1). HELLP Syndrome: Recognition and Perinatal Management. American Family Physician [On-line journal]. Available online at http://www.aafp.org/afp/990901ap/829.html through http://www.aafp.org.

Sibai, B. (2004 May). Diagnosis, Controversies, and Management of the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count. ACOG, High-Risk Pregnancy Series: An Expert’s View v 103 (5 part 1). [On-line journal]. Available online at http://www.mccn.edu/library/ABOG/2005/PMID15121574.pdf#search='test%20haptoglobin' through http://www.mccn.edu.